Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. It is a leading cause of illness and death in many parts of the world. Dengue fever can cause a wide range of symptoms, including fever, headache, muscle and joint pain, nausea, vomiting, and rash. In severe cases, dengue fever can lead to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which can be fatal.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of medications that are commonly used to relieve pain, fever, and inflammation. Examples of NSAIDs include ibuprofen, naproxen, and celecoxib. NSAIDs work by inhibiting the production of prostaglandins, which are involved in the body's inflammatory response.

NSAIDs in Management of Dengue Fever

NSAIDs can be effective in relieving the symptoms of dengue fever, such as pain and fever. However, they should be used with caution in people with dengue fever, as they can increase the risk of bleeding.

How NSAIDs Increase Risk of Bleeding in Dengue?

NSAIDs can increase the risk of bleeding in dengue fever by several mechanisms:

• Platelet dysfunction: NSAIDs can impair the function of platelets, which are necessary for blood clotting.
• Increased capillary permeability: NSAIDs can increase the permeability of capillaries, which are small blood vessels that allow fluid and cells to pass through. This can lead to leakage of blood from the capillaries.
• Gastric irritation: NSAIDs can irritate the stomach lining, which can lead to bleeding.

Contraindications to NSAIDs in Dengue

NSAIDs are contraindicated in the following situations:

• Active bleeding: NSAIDs should not be used in people who are actively bleeding, as they can increase the risk of bleeding.
• History of bleeding disorders: NSAIDs should not be used in people with a history of bleeding disorders, as they can increase the risk of bleeding.
• Peptic ulcer disease: NSAIDs should not be used in people with peptic ulcer disease, as they can irritate the stomach lining and increase the risk of bleeding.
• Dengue fever: NSAIDs should not be used in people with dengue fever, as they can increase the risk of bleeding.

Alternative Medications for Dengue Fever

There are a number of alternative medications that can be used to relieve the symptoms of dengue fever, including:

• Acetaminophen: Acetaminophen is a pain reliever and fever reducer that is generally safe for use in people with dengue fever.
• Opioids: Opioids are strong pain relievers that can be used to relieve severe pain in people with dengue fever.
• Antihistamines: Antihistamines can be used to relieve itching and rash associated with dengue fever.

Conclusion

NSAIDs are contraindicated in dengue fever because they can increase the risk of bleeding. There are a number of alternative medications that can be used to relieve the symptoms of dengue fever.

FAQs

1. Why are NSAIDS contraindicated in dengue?

NSAIDs are contraindicated in dengue because they can increase the risk of bleeding.

2. What are the mechanisms by which NSAIDs increase the risk of bleeding in dengue?

NSAIDs can increase the risk of bleeding in dengue by impairing platelet function, increasing capillary permeability, and irritating the stomach lining.

3. What are the contraindications to NSAIDs in dengue?

NSAIDs are contraindicated in active bleeding, history of bleeding disorders, peptic ulcer disease, and dengue fever.

4. What are the alternative medications for dengue fever?

Alternative medications for dengue fever include acetaminophen, opioids, and antihistamines.

5. What is the recommended treatment for dengue fever?

The recommended treatment for dengue fever is supportive care, which includes rest, fluids, and pain relievers.